Lipoprotein oxidation in cardiovascular disease: chief culprit or innocent bystander?

Transcatheter closure of paravalvular leak secondary to left ventricular peri-annular pseudoaneurysm.

perspective is avoid to carry on as we do considering this entity simplistically as black or white picture—'culprit or innocent bystander.' Since then, large multicentre clinical databases, based on standardized definition, are required to identify criteria that justify the link between clinical sign and/or symptoms and a given pattern of MB as the primary culprit and which move beyond the curr...

Peroxisome proliferator-activated receptor alpha as a genetic determinant of cardiac hypertrophic growth: culprit or innocent bystander?

Hypertrophic Growth : Culprit or Innocent Bystander? as a Genetic Determinant of Cardiac α Peroxisome Proliferator-Activated Receptor Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation 2002;105:1025-1027 Circulation. http://circ.a...

'Dysfunctional' adipose tissue in cardiovascular disease: a reprogrammable target or an innocent bystander?

Enzymatically modified LDL, atherosclerosis and beyond: paving the way to acceptance.

The eLDL (enzymatically modified LDL) hypothesis proposes that modification of LDL during atherogenesis occurs through the action of ubiquitous hydrolytic enzymes. eLDL is recognized by multiple macrophage receptors. Following cellular uptake, eLDL triggers atherosclerotic lesion initiation with reversion or progression depending on the balance between cholesterol insudation and depletion. The ...

The role of vitamin E in atherosclerosis.

Epidemiological and biochemical studies infer that oxidative processes, including the oxidation of low-density lipoprotein (LDL), are involved in atherosclerosis. Vitamin E has been the focus of several large supplemental studies of cardiovascular disease, yet its potential to attenuate or even prevent atherosclerosis has not been realised. The scientific rationale for vitamin E supplements pro...